Hormonal Therapy for Breast Cancer Things have changed now. A new group of hormonal drugs that has been introduced few years ago has almost replaced tamoxifen as the treatment of choice for early stage breast cancer. This new group of drugs known as aromatase inhibitors has been shown to be more effective than tamoxifen over and over again.
This new group of drugs however is not effective in premneopausal women who have been diagnosed with breast cancer. Tamoxifen still remains the hormonal treatment of choice for women with breast cancer who have hormone receptor positive early stage breast cancer.
Hormonal Therapy for Breast Cancer - This new group of drugs known as aromatase inhibitors acts by inhibiting an enzyme called aromatase, which is responsible for production of small amounts of estrogen in post-menopausal women. Estrogen production from the ovaries in premneopausal women is not depended on aromatase hormone, and that is the reason why this drug is not effective in premneopausal women.
Three drugs belonging to the group of aromatase inhibitors are currently FDA approved and available for treatment of breast cancer. These drugs are anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin). All these are active drugs are generally considered to be equally effective.
Aromatase inhibitors may be useful even if a woman has already been started on tamoxifen. Aromatase inhibitors can be taken for five years after completion of five years of tamoxifen. A clinical trial (MA-17) has shown that if Femara is taken for another extra five years after completion of five years of treatment with tamoxifen, this would result in improved outcome. Other trials (ABCSG trial, ARNO trial 95, and ITA trial) have shown that it is beneficial to switch from tamoxifen to aromatase inhibitors after two to three years of treatment with tamoxifen.
Aromatase inhibitors have already shown to be superior to tamoxifen in the treatment of hormone receptor positive metastatic (cancer that has spread to distant organs) breast cancer. In this situation Femara is currently the drug of choice and tamoxifen have moved to second or third position as an option for hormonal therapy.
One thing is clear. The very foundation of tamoxifen as the hormonal treatment of choice is shaking and the aromatase inhibitors are here to stay.
Copyright © Medicineworld.org 2006
Scott William is the webmaster for Medicineworld.org a site dedicated to medical information. For more information regardings breast cancer please visit authors website.
Article Source: http://EzineArticles.com/?expert=Scott_William
Article Source: http://EzineArticles.com/231296
1 ความคิดเห็น:
Colorectal cancer, cancer of the large intestine, is the fourth most common cancer in North America. Many cases of colorectal cancer are associated with low levels of physical activity and with diets that are low in fruits and vegetables. Individuals with a family history of the disease have a higher risk. I crumble with this disease for 5 years also with a lot of scaring thought in my head because i was just waiting for death every day of my life until My Son came to me in the hospital explaining to me that he has find a herbal healer from Nigeria to cure my Colo-Rectal Cancer,I was so shocked with the ideal also i was excited inside of me.My son asked me to let us give him a try because we have really heard a lot of scammer pretending to cure all sort of diseases with herbal medicine and some of them never get a positive result at the end of it all but we was very confident on this herbal doctor,like i said we give him a try and he sent me a herbal medicine to drink for three weeks, Sincerely I'm telling you today I' alive and healthy no more laying on sick bed,No more Colo-Rectal Cancer.I'm sharing this testimony on here for people who are sick to contact this Wonderful man,His name is Dr Itua.And His contact Whatsapp_+2348149277967____Email... drituaherbalcenter@gmail.com.
He can cure those diseases like:
Bladder cancer
Breast cancer
Colorectal cancer
Kidney cancer
Leukemia
Lung cancer
Non-Hodgkin lymphoma
Prostate cancer
Skin cancer
Uterine cancer
Parkinson's,Alzheimer’s disease,Bechet’s disease,Crohn’s disease
,Cushing’s disease,Heart failure,Multiple Sclerosis,Hypertension,Colo_Rectal Cancer,Lyme Disease,Blood Cancer,Brain Cancer,Breast Cancer,Lung Cancer,Kidney Cancer, Spell,Lottery Spell,disease,Schizophrenia,Cancer,Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity Syndrome Fibrodysplasia Ossificans Progressiva.Infertility,Tach Disease ,Epilepsy ,Diabetes ,Coeliac disease,,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma, (measles, tetanus, whooping cough, tuberculosis, polio and diphtheria)Allergic diseases.Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
Syndrome Fibrodysplasia Ossificans ProgresSclerosis,Seizures,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpe ,Copd,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.
Dementia.,Hiv_ Aids,Herpes,Inflammatory bowel disease ,Copd,Diabetes,Hepatitis
Love Spell
Diabetes
แสดงความคิดเห็น